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In a new video, Dr Fazlur Talukdar, a postdoctoral scientist in the Epigenomics and Mechanisms Branch of the International Agency for Research on Cancer (IARC), describes the findings of a recently published study on potential markers of oesophageal squamous cell carcinoma.
In the largest genome-wide DNA methylation study of its kind, the researchers examined the incidence of aberrant epigenome (DNA methylation) profiles – alterations of the DNA methylation patterns, which can be caused by the interaction of agents in an individual’s environment with DNA. They used samples of oesophageal squamous cell carcinoma from nine countries with high incidence of this disease, including countries in Africa, Asia, and South America. The study team found that seven alterations affecting three genes could identify tumours with high sensitivity and specificity.
Talukdar FR, Soares Lima SC, Khoueiry R, Laskar RS, Cuenin C, Pereira Sorroche B, et al.
Genome-wide DNA methylation profiling of esophageal squamous cell carcinoma from global high-incidence regions identifies crucial genes and potential cancer markers
Cancer Res, Published online 19 March 2021;
https://doi.org/10.1158/0008-5472.CAN-20-3445
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