Prediction of acute myeloid leukaemia risk in healthy individuals

As part of a new study by scientists from the International Agency for Research on Cancer (IARC) and partners, published in Nature, researchers performed deep sequencing of DNA from individuals who later developed acute myeloid leukaemia (AML) and individuals who did not. The results, based on the large European Prospective Investigation into Cancer and Nutrition (EPIC) cohort, showed that individuals who later developed AML had more genetic mutations per sample, higher variant allele frequencies (indicating greater clonal expansion), and enrichment of mutations in specific genes. In the future, these findings could enable earlier detection and monitoring and may help to inform intervention.

Abelson S, Collord G, Ng SWK, Weissbrod O, Mendelson Cohen N, Niemeyer E, et al.
Prediction of acute myeloid leukaemia risk in healthy individuals
Nature, Published online 9 July 2018;
https://dx.doi.org/10.1038/s41586-018-0317-6

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