The International Agency for Research on Cancer (IARC) is pleased to announce that the IARC Monographs volume on styrene, styrene-7,8-oxide, and quinoline is now available online.
This volume provides evaluations of the carcinogenicity of styrene, styrene-7,8-oxide, and quinoline. Quinoline and styrene are present in air pollution and in tobacco smoke. Quinoline also occurs in petroleum and shale oil processing, and is found in groundwater and soil at coal tar and creosote-contaminated sites. Quinoline and styrene are high production volume chemicals. Quinoline is used to produce various drugs and dyes. Styrene is primarily used in the production of polystyrene polymers. Styrene-7,8-oxide is primarily used to produce epoxy resins. Styrene-7,8-oxide is the primary metabolite of styrene in humans. Styrene and styrene-7,8-oxide are found in workplace air, particularly in the reinforced plastics and rubber industries. Exposure to these agents may occur in the general population as well as in various occupational settings.
An IARC Monographs Working Group reviewed epidemiological evidence, animal bioassays, and mechanistic and other relevant data to reach conclusions as to the carcinogenic hazard to humans of environmental or occupational exposure to these agents.