Jiri Zavadil
Deputy Branch Head
Epigenomics and Mechanisms
Speciality: Molecular biology, cancer genomics, mechanisms of tumorigenesis
Year | Degree | Major | Institution | Country/Town |
---|---|---|---|---|
1998 | PhD | Biomedicine & Molecular Genetics | Charles University | Czech Republic / Prague |
Current Research Projects
Toxicogenomics of cancer risk agents in experimental models
Collaborators: SG Rozen, LB Alexandrov, S Balbo, RJ Turesky, S Hecht, D Phillips, M Stratton, MM Stampfer, R Herbert, FA Beland, D Mandrioli, M Dusinska, L Sancey, B Busser
Molecular epidemiology of human cancer
Collaborators: B Fervers, B Charbotel, AP Grollman, K Dickman, J Nortier, B Jelakovic, SG Rozen, K Smits, L Schouten, S De Saeger, M De Boevre, Valerie McCormack, J Schuz
Genome topography determinants of cell immortalization and transformation
Collaborators: LB Alexandrov, SG Rozen, E Mathe, T Stopka, MM Stampfer, Z Herceg
Selected Publications
Zhivagui M, Ng AWT, Ardin M, Churchwell MI, Pandey M, Renard C, Villar S, Cahais V, Robitaille A, Bouaoun L, Heguy A, Guyton KZ, Stampfer MR, McKay J, Hollstein M, Olivier M, Rozen SG, Beland FA, Korenjak M, and Zavadil J, Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans. (2019) GENOME RES. 29(4): 521-531.
Huang MN, Yu W, Teoh WW, Ardin M, Jusakul A, Ng AWT, Boot A, Abedi-Ardekani B, Villar S, Myint SS, Othman R, Poon SL, Heguy A, Olivier M, Hollstein M, Tan P, Teh BT, Sabapathy K, Zavadil J, Rozen SG. Genome-scale mutational signatures of aflatoxin in cells, mice, and human tumors. (2017) GENOME RES. 27(9): 1475-1486.
Huskova H, Ardin M, Weninger A, Vargova K, Barrin S, Villar S, Olivier M, Stopka T, Herceg Z, Hollstein M, Zavadil J, Korenjak M. Modeling cancer driver events in vitro using barrier bypass-clonal expansion assays and massively parallel sequencing. (2017) ONCOGENE. 36(43): 6041-6048.
Hollstein M, Alexandrov LB, Wild CP, Ardin M, Zavadil J. Base changes in tumour DNA have the power to reveal the causes and evolution of cancer. (2017) ONCOGENE. 36(2):158-67.
Jelaković B, Castells X, Tomić K, Ardin M, Karanović S, Zavadil J. Renal cell carcinomas of chronic kidney disease patients harbor the mutational signature of carcinogenic aristolochic acid. (2015) INT J CANCER. 136(12): 2967-72.
Scientific Societies Membership
EMGS - Environmental Mutagenesis and Genomics Society
AACR - American Society for Cancer Research
EACR - European Association for Cancer Research
Prizes, Honours
American Association for Cancer Research-Sidney Kimmel Foundation for Cancer Research Fellowship in Basic Research.
AACR-AFLAC Incorporated Scholar in Training Award for the American Association for Cancer Research 94th Annual Meeting.