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The International Agency for Research on Cancer (IARC) is proud to announce that IARC researchers are part of a team that has been awarded a grant of up to £20 million as part of the Grand Challenge, facilitated by Cancer Research UK. The research project, “Mutographs of Cancer: Discovering the causes of cancer through mutational signatures”, is a joint initiative that aims to better define what causes DNA damage and how it leads to cancer. The project is a response to Grand Challenge 3: “Discover how unusual patterns of mutation are induced by different cancer-causing events”.