Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3

Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3
MP Purdue, M Johansson, D Zelenika, JR. Toro, G Scelo, et al.
Nature Genetics 2010, Published online 05/12/2010, DOI doi:10.1038/ng.723

Two genetic loci are associated with renal cell carcinoma (RCC), according to a new report published online this week in Nature Genetics in a study led by IARC scientists in collaboration with colleagues from over 50 different centres. These are the first common genetic variants associated with this type of cancer.
Approximately 200,000 new cases of kidney cancer are diagnosed worldwide each year, with renal cell carcinoma accounting for 90% of all kidney cancer cases. High blood pressure, obesity and smoking are all risk factors for kidney cancer. The study involved 5,970 individuals with renal cell carcinoma and a similar group of controls.
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