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New research led by the International Agency for Research on Cancer (IARC) studies drivers of cell immortalization, a hallmark of cancer, using an experimental carcinogen exposure system and state-of-the-art genomics technologies. The report, published today in the journal Oncogene, identifies novel putative cancer driver genes not yet recognized by large-scale cancer genome sequencing projects. The research highlights the potential for the system’s wider application in complementing tumour sequencing in the discovery and functional characterization of early biomarkers of carcinogenic transformation.
Huskova H, Ardin M, Weninger A, Vargova K, Barrin S, Villar S, et al.
Modeling cancer driver events in vitro using barrier bypass-clonal expansion assays and massively parallel sequencing
Oncogene, Published online 10 July 2017;
http://dx.doi.org/10.1038/onc.2017.215
