Roadmap for investigating epigenome deregulation and environmental origins of cancer

The interaction between the (epi)genetic makeup of an individual and their environmental exposure record is accepted as a determinant factor for most human cancers. In an opinion paper published in the International Journal of Cancer, scientists from the Epigenetics Group at the International Agency for Research on Cancer (IARC) and partners review the state of the science of epigenetics associated with environmental stimuli and cancer risk, highlighting key developments in the field. The article also discusses critical knowledge gaps and research needs and provides guidelines (a roadmap) for investigating epigenetic deregulation and environmental origins of cancer.

Herceg Z, Ghantous A, Wild CP, Sklias A, Casati L, Duthie SJ, et al. Roadmap for investigating epigenome deregulation and environmental origins of cancer
Int J Cancer. Accepted manuscript online 24 August 2017
http://dx.doi.org/10.1002/ijc.31014

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