Epigenome-wide profiling of normal gastric mucosa identifies Helicobacter pylori- and cancer-associated DNA methylome changes

A new study led by scientists from the International Agency for Research on Cancer (IARC) and from the National Cancer Center Seoul (Republic of Korea) investigated the impact of both current and past (eradicated) Helicobacter pylori infection on epigenome-wide changes in normal gastric mucosa collected from study participants in the Republic of Korea. This is the first report of the epigenome-wide analysis of normal gastric mucosa taken from cases and controls representing both H. pylori and gastric cancer status, and the comprehensively characterized epigenome changes might serve as potential biomarkers for early cancer progression in tumour-free gastric mucosa in nationwide gastric cancer screening programmes.

Woo HD, Fernandez-Jimenez N, Ghantous A, Degli Esposti D, Cuenin C, Cahais V, et al.
Genome-wide profiling of normal gastric mucosa identifies Helicobacter pylori- and cancer-associated DNA methylome changes
Int J Cancer. Published online 25 March 2018;
http://dx.doi.org/10.1002/ijc.31381

Read article