Down-regulation of TLR9 expression by beta HPV type 38 and implications for cell cycle control

A new study led by researchers from the International Agency for Research on Cancer (IARC) shows that the cutaneous human papillomavirus (HPV) type 38, a virus suspected to induce skin cancer together with ultraviolet irradiation, negatively affects one key player in the immune response, TLR9. HPV38 viral oncoproteins E6 and E7 suppress the synthesis of TLR9, inhibiting immune-related response pathways and stimulating cell proliferation. The study, published in the Journal of Virology, highlights a novel link between TLR9 and cell cycle regulation.

Down-regulation of toll-like receptor 9 expression by beta human papillomavirus type 38 and implications for cell cycle control
Pacini L, Savini C, Ghittoni R, Saidj D, Lamartine J, Hasan UA, Accardi R, Tommasino M.
Journal of Virology, 2015 Sep 2. pii: JVI.02151-15.
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