A team of scientists from the Section of Environment and Radiation at the International Agency for Research on Cancer (IARC), in collaboration with partners from the Kilimanjaro Clinical Research Institute in Tanzania and the Medical Research Council (MRC) Cancer Unit at the University of Cambridge in the United Kingdom, have successfully completed the CytoSSCAPE feasibility study. The study investigated the use of a “pill-on-a-string” encapsulated sponge to collect cells from the lining of the oesophagus, in a region of East Africa with high rates of oesophageal squamous cell carcinoma. The findings of this feasibility study and an accompanying editorial were published in the International Journal of Cancer.
The device, called the Cytosponge, was found to be safely administered and highly acceptable to community members in Tanzania, paving the way for studies on early detection and etiology. This device was developed by the Fitzgerald laboratory at the MRC Cancer Unit for the routine early detection of Barrett oesophagus, a precursor of oesophageal cancer. Now, for the first time, the Cytosponge device has been used in a Tanzanian community setting as part of the Oesophageal Squamous Cell Carcinoma African Prevention Research (ESCCAPE) project.
Middleton DRS, Mmbaga BT, O’Donovan M, Abedi-Ardekani B, Debiram-Beecham I, Nyakunga-Maro G, Maro V, Bromwich M, Daudi A, Ngowi T, Minde R, Claver J, Mremi A, Mwasamwaja A, Schüz J, Fitzgerald RC, McCormack V.
Minimally invasive oesophageal sponge cytology sampling is feasible in a Tanzanian community setting
Int J Cancer, Published online 31 October 2020;
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