Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes

A new large-scale association analysis coordinated by scientists from the International Agency for Research on Cancer (IARC) and published in Nature Genetics identifies new lung cancer susceptibility loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer. In this analysis, 14 803 cases and 12 262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genome-wide association study (GWAS) analysis of lung cancer in 29 266 cases and 56 450 controls.

McKay JD, Hung RJ, Han Y, Zong X, Carreras-Torres R, Christiani DC, et al.
Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes
Nat Genet. Published online 12 June 2017;
http://dx.doi.org/10.1038/ng.3892

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