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5 Décembre 2022
Colorectal cancer Obesity

Body mass index and molecular subtypes of colorectal cancer

In a new study, researchers from the International Agency for Research on Cancer (IARC) and partner institutions provide evidence suggesting that obesity influences nearly all major pathways involved in colorectal carcinogenesis. The results were published in the Journal of the National Cancer Institute.

The researchers conducted the largest ever analysis of individuals’ body mass index (BMI) and colorectal cancer status. They examined data relating to more than 11 000 controls and almost 12 000 patients with colorectal cancer, including information on the tumour molecular subtypes.

The results of the study show that a higher BMI is associated with an increased risk of colorectal cancer but present little evidence of heterogeneity of the association across individual molecular subtypes. Even though higher BMI was consistently associated with elevated risks of many colorectal cancer types, it was found not to be related to colorectal cancer types related to Lynch syndrome.

Murphy N, Newton CC, Song M, Papadimitriou N, Hoffmeister M, Phipps AI, et al.
Body mass index and molecular subtypes of colorectal cancer
J Natl Cancer Inst, Published online 29 November 2022;
https://doi.org/10.1093/jnci/djac215

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Publication status

Published in section: Actualité du CIRC

Publication date: 5 Décembre, 2022, 0:31

Direct link: https://www.iarc.who.int/fr/news-events/body-mass-index-and-molecular-subtypes-of-colorectal-cancer/

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